ALTERNATIVE LINKS   Preparted by BioTox (Suggestions to: evilanova@umh.es)
(Key words: Alternatives to animal experimentations. 3Rs. In vitro testing. In vitro toxicology)

OUR  BEST RECOMMENDATIONS:
REMA (www.remanet.net) (Spanish Network opf Alternatives)

busca-tox.com (Searching and leaning)

AETOX-GTEMA (Spanish Association of Toxicology  Alternative Group).

ECOPA (European Consensus Platform on AM)
ECVAM
(European Centre for Validation of AM).

ECVAM-SIS (Information Service)
ICCVAM-NICEATM (US Center for Validation AM)
SECTIONS

(_)  Cell lines banks and data bases
(_)  News

(0)
 Main sites on Alternatives
(1) 
Alternative SitesAlternative Sites
(2)  Animal WelfareAnimal Welfare
(3) 
Testing and Regulations

(4)  List Links on Alternatives
(5) 
Method-related Sites
(6)  Funding Sites
(6b) Research Projects on Alternatives
(7)  Good Laboratory Practices
(8)  Miscellaneous
(8)  ICCVAM Agencies

(10)  News Journals
(11)  Brochures Pamphlets

(12)  Notices. (From NTP
Cell Lines banks and data bases:  ECACC European Collection of Cell CulturesDSMZ - The German Collection of Cell Cultures; CABRI Common Access to Biological Resources; ATCC American Type Culture Collection; NIGMS National Institute of General Medical Sciences; The University of Michigan Breast Cell Line/Tissue Bank and Data Base; JCRB Japanese Cancer Research Resources Bank; WFCC World of Culture Collections; ICLC Interlab Cell Line Collection (Cell Line Data Base Intelab Project) 

NEWS: Go to REMA (Spanish platform for alternative) (www.remanet.net)

(0-0) MAIN SITES on ALTERNATIVES

(0-1) REMA (Spanish Network).
[
http://www.remanet.net]
"Red Española pasta el desarrollo de Métodos Alternativos a la Experimentación Animal". Spanish Consensus Platform for the development of Alternative Methods to Animal Experimentation. On the "FOUR" parties concept (Academia, Industry, Administration, and Society-Animal protection) for the 3-Rs principles (Reduction, Refinement and Replacement).

(0-2) ECOPA (European Consensus Platform).
[
http://ecopa.vub.ac.be] European Consensus Platform for the development of Alternative Methods to Animal Experimentation. On the "FOUR" parties concept (Academia, Industry, Administration, and Society-Animal protection) for the 3-Rs principles (Reduction, Refinement and Replacement).

(0-3) AETOX-GTEMA (Spanish Assoc Toxicol. Alternative Group).
[
http://tox.umh.es/aetox/gtema/
] Asociación Española de Toxicología - Grupo Especializado de Trabajo en Métodos Alternativos.

(0-4) ECVAM (European Centre for Validation of Alternative Methods).
[
http://ecvam.jrc.it/]
.

(0-5) ECVAM-SIS (Scientific Information Service of  the European Centre for the Validation of Alternative Methods (ECVAM).
[
http://ecvam-sis.jrc.it/] ECVAM-SIS is designed to establish, maintain and manage a database (SIS) on advanced alternative procedures to animal experiments. SIS is designed to provide full method descriptions including their development and validation status..

(0-6) ICCVAM - NICEATM (US).
[
http://iccvam.niehs.nih.gov] ICCVAM. The Interagency Coordinating Committee on the Validation of Alternative Methods. NICEATM. The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods.

(0-7) ESACT.
[
http://www.esact.org/]
European Society for Animal Cell Technology.

(0-8) EATB.
[
http://www.eatb.de/]
European Association of Tissue Banks.
 

Other gemeral links on alternatives:

 

(1-0) ALTERNATIVE SITES.

(1-9) Alternatives to Use of Live Vertebrates....
[
http://sis.nlm.nih.gov/] National Library of Medicine, NIH, quarterly bibliography with abstracts, V. Hudson & E. DeBerry..

(1-10) Amended EU Council Directive 76/768/EEC - Cosmetic Products.
[
http://europa.eu.int/eur-lex/en/com/pdf/2000/en_500PC0189.pdf]
Proposal to amend EU Council Directive 76/768/EEC on the approximation of the laws of the Member States relating to cosmetic products (2000). To introduce permanently and definitively a prohibition on the performance of experiments on animals for finished cosmetic products in the territory of Member States of the European Union..

(1-11) ECVAM (European Centre for the Validation of Alternative Methods) SIS (Scientific Information Service).
[
http://ecvam-sis.jrc.it/] One of ECVAM's priorities is to establish, maintain and manage a database (SIS) on advanced alternative procedures to animal experiments. SIS is designed to provide full method descriptions including their development and validation status. Furthermore, detailed protocols for their use, test compounds to which they have been applied, and test results, information on user laboratories and details on formal validation studies, are made available..

(1-12) EEC (European Economic Council) European Commission (on AltWeb).
[
http://www.jhsph.edu/~altweb/science/regs/target2000.htm]
Commission Directives identified.  Description of European efforts to reduce and eliminate animal testing..

(1-13) Europa - Scientific Committee for Cosmetic Products and Non-food Products (SCCNFP).
[
http://europa.eu.int/]
The European Commission Directorate General Consumer Policy and Consumer Health Protection.   SCCNFP is sci. advisor to EC with a working group on alternatives to animal testing. Cooperates with ECVAM..

(1-14) FRAME (Fund for the Replacement of Animals in Medical Experiments).
[
http://www.frame.org.uk/index.htm]
Numerous links to alternative testing and animal care sites & listservs..

(1-15) NIEHS and the Use of Alternative Methods in Toxicological Research and Testing.
[
http://www.niehs.nih.gov/oc/factsheets/analt.htm]
Q & A 5-page fact sheet on alternative methods for lay public..

(1-16) NTP (National Toxicology Program) 1998 Overview: Current Directions and Evolving Strategies.
[
http://ntp-server.niehs.nih.gov/Main_Pages/PUBS/1998_overview.html]
Development, validation, and regulatory acceptance of improved alt. toxicol. methods.  Model systems include transgenic mice, nonmammalian species, in vitro cell systems, and computer-based predictive models.  ICCVAM and 1997 report & alt. toxicol. models advisory committee described..

(1-17) NTP (National Toxicology Program) Fiscal Year 1997 Annual Plan Summary.
[
http://ntp-server.niehs.nih.gov/Main_Pages/PUBS/FY97_AP_Summ1.html]
Section on Alternative/Complementary Methods describes ICCVAM, previous funding on alt. models.   "The scope of alternative systems is envisioned to include non-mammalian species, transgenics, use of mechanistic data in hazard identification, and predictive toxicology.".

(1-18) Swedish Fund for Research without Animal Experiments, Links page.
[
http://www.algonet.se/~stifud/links.html]
Links to many alternatives sites including AWIC, NORINA, alt. in higher education..

(1-19) The Norwegian Reference Centre for Lab. Animal Sci. & Alternatives  - Alternatives Databases.
[
http://oslovet.veths.no/databases.html]
Animal welfare links, link to CAAT (mirror site)..

(1-20) UC (University of California - Davis) Center for Animal Alternatives Links page.
[
http://www.vetmed.ucdavis.edu/Animal_Alternatives/weblinks.htm]
Electronic mailing lists include AltAnim (Alternatives to Animals Forum) and the Rat Talk listserv.  Web site links include AWIC, NetVet, and USDA/APHIS.  Another page gives alternatives terminology to use in online searches.

 

(2-0) ANIMAL WELFARE.

(2-21) AltWeb Links.
[
http://altweb.jhsph.edu/about-us/links.htm]
Links to U.S. & foreign sites re: animal welfare & regulations; also regs. themselves..

(2-22) APHIS (Animal and Plant Health Inspection Services), USDA, Animal Care Home Page.
[
http://www.aphis.usda.gov/] Protects America's animal and plant resources by safeguarding resources from exotic invasive pests and diseases, monitoring and managing agricultural pests and diseases existing in the United States, resolving and managing trade issues related to animal or plant health, and ensuring the humane care and treatment of animals..

(2-23) ASTM (Am. Soc. for Testing and Materials).
[
http://www.astm.org/]
Standard methods for animal testing.  Methods include GPMT [F720-81(1996)e1], delayed hypersensitivity, acute oral toxicity, eye irrit..

(2-24) BgVV (Bundesinstitut fuer gesunheitlichen Verbraucherschutz und Veterinaermedizin).
[
http://www.bgvv.de/]
Animal protection, care, and use in testing.  Web pages are in German and have not been translated as of May 22, 1998..

(2-25) FRAME (Fund for the Replacement of Animals in Medical Experiments).
[
http://www.frame.org.uk/index.htm]
Numerous links to alternative testing and animal care sites & listservs.

 

(3-0) TESTING AND REGULATIONS.

(3-26) EPA   (U.S. Environmental Protection Agency) skin sensitization guidelines via AltWeb.
[
http://altweb.jhsph.edu/~altweb/regulations/EPA/2600_ss.htm]
OPPT 40 CFR 870.2600 Skin Sensitization (downloaded Jun. 1997 public draft).  Full text of harmonized test guideline used OPPT 40 CFR 798.4100 Dermal Sensitization; OPP 81-6 Dermal Sensitization (Pesticide Assessment Guidelines, subdivision F--Haz. Evaln.; Human & Domestic Animals, 1982; and OECD 406 Skin Sensitization. If positive in LLNA, further testing not needed..

(3-27) (Center for Food Safety and Applied Nutrition) - Office of Food Additive Safety.
[
http://www.cfsan.fda.gov/~dms/opa-tg1.html]
Toxicological testing of food additives. Safety evaluation for a food additive involves assigning the additive to a concern level based on information on the additive's structural configuration and an estimation of exposure. This document has been prepared to recommend the minimum toxicity tests to be performed for safety evaluation of indirect and direct additives based on levels of concern.  1997 update to reformat. Toxicity testing (protocols in FDA Redbook) does not include skin tests..

(3-28) ASTM (Am. Soc. for Testing and Materials).
[
http://www.astm.org/]
Methods include GPMT [F720-81(1996)e1], delayed hypersensitivity, acute oral toxicity, eye irrit..

(3-29) CPSC (Consumer Product Safety Commission) Hazard Assessment and Reduction Program and Regulated Products Program.
[
http://cpsc.gov/]
Consumer Products Safe Testing Act; Animal testing policy 49 FR 22522-22523 (1984); Guidelines for determining chronic toxicity according to Federal Hazardous Substance Act. Poison Prevention Pkg. Act..

(3-30) DoT Research and Special Programs Administration.
[
http://www.rspa.dot.gov/] Performance-oriented packaging standards; Changes to classification, hazard communication, packaging, based on UN standards and agency initiative, 55 FR 52402-52729; 49 CFR 173 (1990).  1994 DOT Strategic Plan.  Statute is Federal Hazardous Materials Transportation Law.  DoT has accepted the Corrositex method to predict corrosivity of test materials..

(3-31) EPA (U.S. Environmental Protection Agency) skin sensitization guidelines via AltWeb.
[
http://altweb.jhsph.edu/~altweb/regulations/EPA/2600_ss.htm]
OPPT 40 CFR 870.2600 Skin Sensitization (downloaded Jun. 1997 public draft).  Full text of harmonized test guideline used OPPT 40 CFR 798.4100 Dermal Sensitization; OPP 81-6 Dermal Sensitization (Pesticide Assessment Guidelines, subdivision F--Haz. Evaln.; Human & Domestic Animals, 1982; and OECD 406 Skin Sensitization. If positive in LLNA, further testing not needed..

(3-32) EPA NCEA (National Center for Environmental Assessment).
[
http://www.epa.gov/ncea/] Risk guidelines, exposure factors, integrated model evaluation system..

(3-33) EPA OPPT (Office of Pollution Prevention and Toxics).
[
http://www.epa.gov/opptintr/chemtest/]
Describes chemicals not covered in purview of TSCA.  TSCA sections, Master Testing List, Screening Information Dataset (SIDS), etc..

(3-34) FDA CBER (Center for Biologics Evaluation and Research) Guidelines/Guidances.
[
http://www.fda.gov/cber/] Guidance and draft guidance.  Files available for download in various formats.  No guidelines obviously related to contact hypersensitivity..

(3-35) FDA CDER (Center for Drug Evaluation and Research) Regulatory and Scientific Guidance.
[
http://www.fda.gov/cder/regulatory/default.htm]
Files available for download in various formats.  Clinical, bioequivalence and solubility, some preclinical testing regulatory guidance..

(3-36) ICH (International Conference on Harmonisation).
[
http://www.pharmweb.net/pwmirror/pw9/ifpma/ich1.html]
Tech. requirements for registration of pharmaceuticals for human use.  Guidelines for toxicity testing (no obvious one for dermal sensitization) can be downloaded (pdf)..

(3-37) This FDA CFSAN Food additives page available at AlWeb.
[
http://altweb.jhsph.edu/~altweb/regulations/food-additives.htm]
.

(3-38) Amended EU Council Directive 76/768/EEC - Cosmetic Products.
[
http://europa.eu.int/eur-lex/en/com/pdf/2000/en_500PC0189.pdf]
Proposal to amend EU Council Directive 76/768/EEC on the approximation of the laws of the Member States relating to cosmetic products (2000). To introduce permanently and definitively a prohibition on the performance of experiments on animals for finished cosmetic products in the territory of Member States of the European Union..

(3-39) BgVV (Bundesinstitut fuer gesunheitlichen Verbraucherschutz und Veterinaermedizin).
[
http://www.bgvv.de/]
Animal protection, care, and use in testing. [English version available].

(3-40) EEC (European Economic Council) European Commission on AltWeb.
[
http://altweb.jhsph.edu/~altweb/regulations/target2000.htm]
Commission Directives identified.  Description of European efforts to reduce and eliminate animal testing..

(3-41) European Convention for the protection of vertebrate animals used for exptl. & other sci. purposes.
[
http://www.uku.fi/laitokset/vkek/Sopimus/convention.html]
Council of Europe guidelines for animal welfare in testing.  Full text of guidelines..

(3-42) ICH (International Conference on Harmonisation).
[
http://www.ifpma.org/ich1.html]
Tech. requirements for registration of pharmaceuticals for human use.  Guidelines for toxicity testing (no obvious one for dermal sensitization) can be downloaded (pdf)..

(3-43) MDSS (Medical Device Safety Service).
[
http://www.mdss.com/MDD/standards.htm]
Standards in the Official Journal of the European Communities.  Testing standards include EN 10993-10 (based on ISO 10993-10: 1995).  EN 10993-10 is on Biol. Evaluation of Medical Devices-Part 10: Tests for Irritation and Sensitisation..

(3-44) OECD (Organization for Economic Co-operation and Development).
[
http://www.oecd.org/]
Links to test guidelines, description of cooperative efforts in chemicals programme.  Testing and assessment is one link. OECD Guidelines for the Testing of Chemicals availability..

(3-45) United Kingdon House of Lords Select Committee on Animals in Scientific Procedures Report, [July 24, 2002 - 82 pages].
[
http://www.publications.parliament.uk/pa/ld/ldanimal.htm]
On July 24, 2002, a select committee of the British Parliament's House of Lords released its report on the use of animals in scientific procedures. The report was the result of a year of investigation, hearings, and consultations by the committee with a wide range of representatives from both the biomedical research and animal rights activist communities..

 

(4-0) LISTS LINKS ON ALTERNATIVES.

(4-46) AltWeb.
[
http://altweb.jhsph.edu/] Top-notch resource on many issues related to alternative testing, animal welfare, and guidelines & regulations both in the US and the international community..

(4-47) ECVAM - The European Centre for the Validation of Alternative Methods.
[
http://ecvam-sis.jrc.it/] Validating methods and strategies to reduce or replace the use of live animals in laboratory studies..

(4-48) FRAME (Fund for the Replacement of Animals in Medical Experiments).
[
http://www.frame.org.uk/index.htm]
Numerous links to alternative testing and animal care sites & listservs..

(4-49) Lab Animal Magazine Links Page.
[
http://www.labanimal.com] Countless links related to alternative methods, animal research, and animal welfare, resources, and publications..

(4-50) Laboratory Animals Internet Links (from NetVet Veterinary Resources).
[
http://www.lal.org.uk] International organizations related to the field of laboratory animal medicine & science..

(4-51) NCA (The Netherlands Centre Alternatives to Animal).
[
http://www.nca-nl.org/]
NCA is the central point in the Netherlands for coordinating research and disseminating information on alternatives to animal experiments. One of its important tasks is to support the Alternatives to Animal Experiments Platform, in which the Dutch government, industry and animal protection organisations collaborate. The NCA database comprises 3Rs research projects..

(4-52) NSSN Search for Standards.
[
http://www.nssn.org/search.html]
Adopted modifications of ISO 10993-10: 1995 are ANSI/AAMI/ISO 10993-10-1995, EN ISO 10993-10, and BS ISO 10993-10 for irritation and sensitization.  Other results listed 85 toxicity testing stds.: ASTM, BSI, CSA, ISO, DoD, ANSI, CNS, CHI, CEN..

(4-53) Swedish Fund for Research without Animal Experiments, Links page.
[
http://www.algonet.se/~stifud/links.html]
Swedish Fund for Research without Animal Experiments.  Links to many alternatives sites including AWIC, NORINA, alt. in higher education..

(4-54) UC (University of California - Davis) Center for Animal Alternatives Links page.
[
http://www.vetmed.ucdavis.edu/Animal_Alternatives/weblinks.htm]
Electronic mailing lists include AltAnim (Alternatives to Animals Forum) and the Rat Talk listserv.   Web site links include AWIC, NetVet, and USDA/APHIS.  Another page gives alternatives terminology to use in online searches..

 

(5-0) METHOD-RELATED SITES.

(5-55) EECDRG (European Environmental and Contact Dermatitis Research Group).
[
http://www.sdu.dk/health/homepages/eecdrg/links.htm]
Members, links, abstracts.  Links to DermIS, the Dermatology Internet Service..

(5-56) Trans-NIH Xenopus Initiative Web Site.
[
http://www.nih.gov/science/models/xenopus/]
The NIH has recently constructed this excellent resource on Xenopus research and initiatives. The site was developed to help keep the public aware of NIH's progress and plans regarding support of the genomic and genetic needs for Xenopus research. The site also provides links to community resources and to information about courses, meetings and publications..

(5-57) Xenopus tropicalis resource.
[
http://minerva.acc.virginia.edu/~develbio/trop/]
A group that is developing X. tropicalis as a model organism, led by Dr. Robert Grainger at UVA. This work is supported by NIH grant RR13221.

 

(6-0) FUNDING SITES.

(6-58) Funding Sources listed by country.
[
http://altweb.jhsph.edu/databases/funding/funding.htm]
AltWeb list of funding sources available (domestic and international).

(6-59) NIH Office of Extramural Research Small Business Innovative Research (SBIR) Contract Proposals pages.
[
http://grants.nih.gov/grants/funding/sbir.htm]
.

 

(7-0) GOOD LABORATORY PRACTICES.

(7-60) OECD's Work on Good Laboratory Practice (GLP) and Compliance Monitoring.
[
http://www.oecd.org/env/glp] The Organisation for Economic Co-operation and Development's (OECD) main page on GLPs. Many links to relevant materials..

(7-61) EPA's "Good Laboratory Practice Standards" (40CFR160).
[
http://iccvam.niehs.nih.gov/docs/EPA/epa-glp.htm]
EPA's regulations for good laboratory practices (GLPs). In plain text..

(7-62) FDA's "Good Laboratory Practice for Nonclinical Laboratory Studies" (21CFR58).
[
http://iccvam.niehs.nih.gov/docs/FDA/fda-glp.htm]
FDA's regulations for good laboratory practices (GLPs). In plain text..

 

(8-0) MISCELLANEOUS.

(8-63) CAAT grants from 1982 to 2003.
[
http://caat.jhsph.edu/programs/grants/grants.htm]
Summary of Research Grants.

(8-64) Modelling Conract Dermatities.
[
http://caat.jhsph.edu/programs/grants/98-99grants/magee.htm]
"A New Approach to Modeling Contact Dermatitis" Phillip S. Magee, PhD, BIOSAR REsearch Project, Vallejo, CA, describes (computational chem.).

(8-65) Research Grants 1998-1999,.
[
http://caat.jhsph.edu/programs/grants/98-99grants/grants98-99.htm]
Summary of Research Grants for Non-Scientists.

(8-66) ALTEX - Alternativen zu Tierexperimenten (Alternatives to Animal Experiments).
[
http://www.altex.ch/]
News, links, online order form for ALTEX..

(8-67) EECDRG (European Environmental and Contact Dermatitis Research Group).
[
http://www.sdu.dk/health/homepages/eecdrg/links.htm]
Members, links, abstracts.  Links to DermIS, the Dermatology Internet Service..

(8-68) Eur-Lex (Europeae Unionis Lex, a portal to European union law).
[
http://www.europa.eu.int/eur-lex/en/index.html]
European Union law & regulatory documents available for downloading in pdf and html formats.  See search results on animal testing..

(8-69) FRAME (Fund for the Replacement of Animals in Medical Experiments).
[
http://www.frame.org.uk/index.htm]
Numerous links to alternative testing and animal care sites & listservs..

(8-70) IEXAS (The Institute of Experimental Animal Science), Osaka University Medical School.
[
http://hayato.med.osaka-u.ac.jp/]
Lab. animal care, livestock diseases..

(8-71) Laboratory Animals Internet Links (from NetVet Veterinary Resources).
[
http://www.lal.org.uk] Nine-page list of organizations related to the field of laboratory animal medicine & science..

(8-72) SCOPE (Scientific Committee on Problems of the Environment) Annual Report.
[
http://www.icsu-scope.org/] SCOPE & IPCS Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC).  Describes workshops including SGOMSEC 13, Alt. methods for Safety Assessment of Chemicals. Workshop held in Feb. 1998 in London, UK..

(8-73) Swedish Fund for Research without Animal Experiments, Links page.
[
http://www.algonet.se/~stifud/links.html]
lLinks to many alternatives sites including AWIC, NORINA, alt. in higher education..

(8-74) The Norwegian Reference Centre for Lab. Animal Sci. & Alternatives Databases.
[
http://oslovet.veths.no/databases.html]
Animal welfare links, link to CAAT (mirror)..

 

(9-0) ICCVAM AGENCIES.

(9-75) ATSDR (Agency for Toxic Substances and Disease Registry).
[
http://www.atsdr.cdc.gov/] ATSDR performs specific functions concerning the effect on public health of hazardous substances in the environment..

(9-76) CPSC (Consumer Product Safety Commission) Hazard Assessment and Reduction Program and Regulated Products Program.
[
http://cpsc.gov/]
Consumer Products Safe Testing Act; Animal testing policy 49 FR 22522-22523 (1984); Guidelines for determining chronic toxicity according to Federal Hazardous Substance Act. Poison Prevention Pkg. Act.  No testing information links from home page..

(9-77) DoT (Department of Transportation) Research and Special Programs Administration.
[
http://www.rspa.dot.gov/] Performance-oriented packaging standards; Changes to classification, hazard communication, packaging...based on UN standards and agency initiative, 55 FR 52402-52729; 49 CFR 173 (1990).  1994 DOT Strategic Plan.  Statute is Federal Hazardous Materials Transportation Law.   DoT has accepted the Corrositex method to predict corrosivity of test materials..

(9-78) EPA NCEA (National Center for Environmental Assessment).
[
http://www.epa.gov/ncea/] Risk assessment; risk guidelines, exposure factors, integrated model evaluation system..

(9-79) EPA OPPT (Office of Pollution Prevention and Toxics).
[
http://www.epa.gov/opptintr/chemtest]
Describes chemicals not covered in purview of TSCA.  TSCA sections, Master Testing List, Screening Information Dataset (SIDS), etc..

(9-80) FDA CBER (Center for Biologics Evaluation and Research) Guidelines/Guidances.
[
http://www.fda.gov/cber/] FDA CBER guidance and draft guidance.  Files available for download in various formats.   No guidelines obviously related to contact hypersensitivity..

(9-81) FDA CDER (Center for Drug Evaluation and Research) Regulatory Guidance.
[
http://www.fda.gov/cder/regulatory/default.htm]
Files available for download in various formats.   Clinical, bioequivalence and solubility, some preclinical testing regulatory guidance.   No obvious contact hypersensitivity..

(9-82) FDA CDRH (Center for Devices and Radiological Health) Immunotoxicity Testing Guidance (May 6, 1999).
[
http://www.fda.gov/cdrh/ost/ostggp/immunotox.html]
Immunotoxicity testing guidance (May 6, 1999). FDA modification of ISO-10993 (adopted General Program Memorandum G95-1 in May 1995.  Full text of guidance. This guidance provides assessment of the types of testing currently available for evaluating potential adverse effects of biomaterials on the immune system.    LLNA is mentioned in Table 3, Examples of Tests, Indicators, and Models for the Evaluation of Immune Responses..

(9-83) National Library of Medicine (V. Hudson alt. tox. bibliographies).
[
http://sis.nlm.nih.gov/] NLM bibliographies with abstracts on Alternatives to Use of Live Vertebrates..

(9-84) NIEHS Alternative Models, Toxicology Operations Branch.
[
http://dir.niehs.nih.gov/dirtob/stokes.htm]
Collaborative development and validation of improved (alt.) animal models and toxicol. res. methods.  Gives publications by Dr. W.S. Stokes..

(9-85) NIEHS Alternative Systems Group.
[
http://dir.niehs.nih.gov/dirlt/burkhart.htm]
Gives overview of research on correlation of induced mutation in cells, rodents, and aquatic species..

(9-86) NIEHS and the Use of Alternative Methods in Toxicological Research and Testing.
[
http://www.niehs.nih.gov/oc/factsheets/analt.htm]
Q & A 5-page fact sheet on alternative methods for lay public..

(9-87) NIEHS, Transgenic Model Studies.
[
http://ntp-server.niehs.nih.gov/Main_Pages/transgen/TransgenicPage.html]
NIEHS Cancer Biology Group, Lab. of Environ. Carcinogenesis and Mutagenesis, NTP.  Test protocols in p53-deficient and TG.AC transgenic mice.   Description of res. initiatives, hypothesis, approach, & publications..

(9-88) NTP (National Toxicology Program) Fiscal Year 2001 Annual Plan Summary.
[
http://ntp-server.niehs.nih.gov/htdocs/2001ap/ap2001.pdf]
Section on Alternative/Complementary Methods describes ICCVAM, previous funding on alt. models.    The scope of alternative systems is envisioned to include non-mammalian species, transgenic species, genetically engineered in vitro cell systems, microchip array technology, and computer-based predictive toxicology models..

(9-89) NTP 2002 Overview: Current Directions and Evolving Strategies.
[
http://ntp-server.niehs.nih.gov/Main_Pages/PUBS/2002CurrentDirections.pdf]
Development, validation, and regulatory acceptance of improved alt. toxicol. methods.  Model systems include transgenic mice, nonmammalian species, in vitro cell systems, microchip array technology, and computer-based predictive models.   ICCVAM and SACATM described..

 

(10-0) NEWS JOURNALS.

(10-90) "Corrositex® Report Released" (NIEHS) Jun. 22, 1999.
[
http://www.niehs.nih.gov/oc/news/corros.htm]
"Corrositex® Report Released" (NIEHS) Jun. 22, 1999.

(10-91) "Drop of 30 Percent in use of Animals(NIEHS) Oct. 3, 2001             http://www.niehs.nih.gov/oc/news/anitest2.htm             "Drop of 30 Percent in use of Animals in Some Tests Could Be Quickly Achieved Through Use of Cells, U.S. Says" (NIEHS) Oct. 3, 2001             http://www.niehs.nih.gov/oc/news/anitest2.htm.
[
http://www.niehs.nih.gov/oc/news/corros.htm]
"Corrositex® Report Released" (NIEHS) Jun. 22, 1999.

(10-92) "Good News for Guinea Pigs" (Science Magazine) Oct. 02, 1998.
[
http://www.sciencemag.org/content/vol282/issue5386/r-samples.shtml]
"Good News for Guinea Pigs" (Science Magazine) Oct. 02, 1998.

(10-93) "More Valid, Less Guinea Pigs" (Lab Animal Magazine) Nov. 1998.
[
http://www.labanimal.com] "More Valid, Less Guinea Pigs" (Lab Animal Magazine) Nov. 1998.

(10-94) "New NTP Centers Meet the Need to Know" (EHP) Magazine) Oct. 1998.
[
http://ehpnet1.niehs.nih.gov/docs/1998/106-10/niehsnews.html]
"New NTP Centers Meet the Need to Know" (Environmental Health Perspectives (EHP) Magazine) Oct. 1998.

(10-95) "New Tricks for an Old Assay"(EHP) Magazine) Oct. 1998.
[
http://ehpnet1.niehs.nih.gov/members/1998/106-10/innovations.html]
"New Tricks for an Old Assay" (Environmental Health Perspectives (EHP) Magazine) Oct. 1998.

(10-96) "NIEHS' Dr. Stokes Receives Humane Society Award" (NIEHS) Oct. 29, 1998.
[
http://www.niehs.nih.gov/oc/news/stokawd.htm]
"NIEHS' Dr. Stokes Receives Humane Society Award" (NIEHS) Oct. 29, 1998.

(10-97) "Smoothing the Way for Animal Alternatives" (Science Magazine) Apr. 04, 1997.
[
http://www.sciencemag.org/content/vol276/issue5309/r-samples.shtml]
"Smoothing the Way for Animal Alternatives" (Science Magazine) Apr. 04, 1997.

(10-98) "Stokes Recognized" (EHP) Feb. 1999.
[
http://ehpnet1.niehs.nih.gov/docs/1999/107-2/niehsnews.html#stokes]
"Stokes Recognized" (Environmental Health Perspectives) Feb. 1999.

(10-99) "U.S. scientists endorse change in animal testing" CNN Interactive Sept. 21, 1998.
[
http://iccvam.niehs.nih.gov/methods/llnadocs/cnnstory.htm]
"U.S. scientists endorse change in animal testing" (originally appeared on CNN Interactive, reproduced with permission from Reuters) Sept. 21, 1998.

(10-100) Environmental Health Perspectives Issue Updates Alternative Testing Advances (NIEHS) Jun. 22, 1998.
[
http://www.niehs.nih.gov/oc/news/stokes2.htm]
Environmental Health Perspectives Issue Updates Alternative Testing Advances (NIEHS) Jun. 22, 1998.

(10-101) New Agency Review  Skin Sensitivity Test (NIEHS) Sept. 10, 1998.
[
http://www.niehs.nih.gov/oc/news/animalt.htm]
New Agency Group to Review Proposed Use of Skin Sensitivity Test Using Fewer Animals (NIEHS) Sept. 10, 1998.

(10-102) Reports Progress in Using Fewer Animals, (NIEHS) Feb. 11, 2002.
[
http://www.niehs.nih.gov/oc/news/iccvam.htm]
"Federal Government Reports Progress in Using Fewer Animals, More Humane Tests for Product Safety Evaluations" (NIEHS) Feb. 11, 2002.

(10-103) U.S. Agencies Agree on How to Bring Alternative Testing Methods (NIEHS) - Mar. 13, 1997.
[
http://www.nih.gov/news/pr/mar97/niehs-13.htm]
U.S. Agencies Agree on How to Bring Alternative Testing Methods Into Use to Supplement, Replace or Improve Current Tests (NIEHS) - Mar. 13, 1997.

 

(11-0) BROCHURES PAMPHLETS.

(11-104) Animals in Research The Importance of Animals in the Science of Toxicology.
[
http://www.toxicology.org/publicoutreach/air/brochure.html]
Society of Toxicology Brochure, March 1999.

(11-105) NIEHS and the Use of Alternative Methods in Toxicological Research and Testing.
[
http://www.niehs.nih.gov/oc/factsheets/analt.htm]
NIEHS Fact Sheet and Pamphlets Page. Fact sheet on toxicology and carcinogenicity studies using animals, the pursuit of alternative methods (including in vitro methods and computer models), appreciation of the 3 R's, and NIEHS' role in advancing these technologies and developing alternative methods.

(11-106) Respect for Life Why Animal Research?.
[
http://www.niehs.nih.gov/oc/factsheets/fsmenu.htm]
NIEHS Fact Sheet and Pamphlets Page.

(11-107) You and Your Genes Making it in a Tough Environment.
[
http://www.niehs.nih.gov/kids/genes/home.htm]
NIEHS Kid's Page. NIH Publication # 98-4367.

 

(12-0) NOTICES. (FROM NTP).

(12-108) Advisory Committee for Alternative Toxicological Methods (SACATM).
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/SACATM_FR.html]
Notice of establishment of the Scientific Advisory Committee for Alternative Toxicological Methods (SACATM) - March 13, 2002 (67 FR 11358).

(12-109) Announcement. Availability of the validation and acceptance of toxicological test methods.
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/ICCVAM_FR.html]
Announcement of the availability of the validation and regulatory acceptance of toxicological test methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), NIH Publication 97-3981. - Mar. 13, 1997 (62 FR 11901).

(12-110) current validation status of the Frog Embryo Teratogenesis Assay--Xenopus (FETAX),.
[
http://ntp-server.niehs.nih.gov/htdocs/liason/May16to18FETAXmtgFR.html]
Notice of Expert Panel Meeting ( May 16 - 18, 2000) to assess the current validation status of the Frog Embryo Teratogenesis Assay--Xenopus (FETAX), an in vitro method proposed for evaluating the developmental toxicity potential of chemicals - Mar. 13, 2000 (65 FR 13289).

(12-111) EPISKIN ™, EpiDerm™ , and Rat Skin Transcutaneous Electrical Resistance Methods Sep 2001.
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/RSkinCorrosivity_FR.html]
Availability of BRD: the EPISKIN ™, EpiDerm™ , and Rat Skin Transcutaneous Electrical Resistance Methods: In Vitro Test Methods Proposed for Assessing the Dermal Corrosivity Potential of Chemicals; Proposed ICCVAM Test Method Recommendations and Request for Public Comment - Sep. 28, 2001 (66 FR 49685).

(12-112) Evaluation of the Revised Up-and-Down Procedure (UDP) Feb 2000.
[
http://ntp-server.niehs.nih.gov/htdocs/liason/ICCVAMUpDownFR.html]
Request for Data and Nomination of Expert Scientists to Participate in the Independent Peer Review Evaluation of the Revised Up-and-Down Procedure (UDP) for Assessing Acute Oral Toxicity - Feb. 18, 2000 (65 FR 8385).

(12-113) Expert Scientists for an Independent Peer Review Evaluation of In Vitro Estrogen Receptor (ER) and Androgen Receptor (AR).
[
http://ntp-server.niehs.nih.gov/htdocs/liason/EDScreening_FR_2001Mar9.html]
NICEATM, in collaboration with ICCVAM, requests Data and Nominations of Expert Scientists for an Independent Peer Review Evaluation of In Vitro Estrogen Receptor (ER) and Androgen Receptor (AR) Binding and Transcriptional Activation Assays for Endocrine Disruptor Screening - Mar. 23, 2001 (66 FR 16278).

(12-114) Federal Register Notices ( linked from the NTP web site).
[
http://ntp-server.niehs.nih.gov/Main_Pages/Announcements.html]
Federal Register Notices ( linked from the NTP web site).

(12-115) Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses Sept 2001.
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/NICEATMIVWkspRpt_FR.html]
Notice of the Report on the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity; Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity; Request for Public Comment - Sep.r 28, 2001 (66 FR 49686).

(12-116) Guidelines for Submissions to the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Dec 1999.
[
http://ntp-server.niehs.nih.gov/htdocs/liason/ICCVAMGuideFR.html]
Availability and Request for Comments on the Revised Guidance Document: Evaluation of the Validation Status of Toxicological Methods: General Guidelines for Submissions to the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) - Dec. 2, 1999 (64 FR 67579).

(12-117) In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of Chemicals - Jul. 31, 2002 (67 FR 49706).
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/CorrFinalRpt10Jul02FR.html]
Availability of the Report, Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Evaluation of EPISKIN™, EpiDerm™ (EPI-200), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay:.

(12-118) Meeting   Murine Local Lymph Node Assay (LLNA Jul 1998.
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/ICVAAM_LLNA_FR.html]
Notice of Meeting to Review the Murine Local Lymph Node Assay (LLNA) as an Alternative Test Method for Contact Hypersensitivity; Request for Comments - Jul. 10, 1998 (63 FR 37405).

(12-119) meeting (Conference Call) of the National Toxicology Program Special Emphasis Panel (NTPSEP) Apr 1999.
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/CorrositexTeleconFR.html]
Announcement of a public meeting (Conference Call) of the National Toxicology Program Special Emphasis Panel (NTPSEP) on April 22, 1999, to agree on the final report of the public meeting held on January 21, 1999, where an independent peer review of Corrositex®, a test method for dermal corrosivity was conducted - Apr. 13, 1999 (64 FR 18040).

(12-120) Meeting of the Advisory Committee Feb 2000.
[
http://ntp-server.niehs.nih.gov/htdocs/liason/ACATMMar7_82kFR.html]
Meeting of the Advisory Committee on Alternative Toxicological Methods on March 7-8, 2000, at NIEHS, 111 Alexander Drive, RTP, NC - Feb. 16, 2000 (65 FR 7878).

(12-121) Meeting of the Advisory Committee Jul 1998.
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/AltToxMtg_FR.html]
Announcement of a meeting of the Advisory Committee on Alternative Toxicological Methods - Jul. 28, 1998 (63 FR 40302).

(12-122) Meeting to Review the Corrositex Assay Oct 1998.
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/Corrositex_FR.html]
Notice of Meeting to Review the Corrositex Assay as an Alternative Test Method for assessing the skin corrosivity potential of chemicals; Request for Comments - Oct. 20, 1998 (63 FR 57303).

(12-123) Meeting. Pprocedures and activities of NICEATM and ICCVAM.
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/ICCVAM_11_97.html]
Notice of meeting to discuss the procedures and activities of NICEATM and ICCVAM - Oct. 27, 1997 (62 FR 55649).

(12-124) Report of the Interagency Coordinating Committee  (ICCVAM) Febn 2002.
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/ICCVAMAnnRptFR.html]
Availability of the Annual Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): Notice of Availability - Feb. 7, 2002 (67 FR 5845).

(12-125) request for comments on test methods undergoing Jul 1998.
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/ICCVAM_RFCmts_FR.html]
Announcement of a request for comments on test methods undergoing review by ICCVAM and NICEATM - Jul. 28, 1998 (63 FR 40303).

(12-126) Request for comments on validation and acceptance of alternative testing methods.
[
http://ntp-server.niehs.nih.gov/htdocs/iccvam/AppendixG.html]
Notice of a request for comments on validation and acceptance of alternative testing methods - invitation to interested parties to provide information for consideration in the formulation of criteria and processes - Dec. 07, 1994 (59 FR 63100).

(12-127) TEST METHODS PAGE..
[
http://iccvam.niehs.nih.gov/methods/review.htm]
FOR MORE RECENT FEDERAL REGISTER NOTICES, PICK THE RELATED METHOD FROM THE.

(12-128) The Revised Up-and-Down Procedure (NIH) Feb 2002.
[
http://ntp-server.niehs.nih.gov/htdocs/Liason/RevisedUPD_NICEATMFR.html]
Availability of the UDP report: "The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals," NIH Publication 02-4501 - Feb. 7, 2002 (67 FR 5842).

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