ALTERNATIVE LINKS
Preparted
by BioTox (Suggestions to: evilanova@umh.es)
(Key words: Alternatives to animal experimentations. 3Rs. In vitro testing. In
vitro toxicology)
| OUR
BEST RECOMMENDATIONS: REMA (www.remanet.net) (Spanish Network opf Alternatives) busca-tox.com (Searching and leaning) AETOX-GTEMA (Spanish Association of Toxicology Alternative Group). |
ECOPA (European
Consensus Platform on AM)
ECVAM (European Centre for Validation of AM). ECVAM-SIS (Information Service) ICCVAM-NICEATM (US Center for Validation AM) |
||
| SECTIONS (_) Cell lines banks and data bases (_) News (0) Main sites on Alternatives (1) Alternative SitesAlternative Sites |
(2) Animal
WelfareAnimal
Welfare
(3) Testing and Regulations (4) List Links on Alternatives (5) Method-related Sites (6) Funding Sites (6b) Research Projects on Alternatives |
(7) Good Laboratory Practices (8) Miscellaneous (8) ICCVAM Agencies (10) News Journals (11) Brochures Pamphlets (12) Notices. (From NTP |
|
(0-1)
REMA (Spanish Network).
[http://www.remanet.net] "Red Española
pasta el desarrollo de Métodos Alternativos a la Experimentación Animal". Spanish Consensus Platform for the development of Alternative Methods to
Animal Experimentation. On the "FOUR" parties concept (Academia, Industry,
Administration, and Society-Animal protection) for the 3-Rs principles (Reduction,
Refinement and Replacement).
(0-2)
ECOPA (European
Consensus Platform).
[http://ecopa.vub.ac.be] European Consensus Platform for the
development of Alternative Methods to Animal Experimentation. On the "FOUR"
parties concept (Academia, Industry, Administration, and Society-Animal protection) for
the 3-Rs principles (Reduction, Refinement and Replacement).
(0-3)
AETOX-GTEMA (Spanish Assoc Toxicol. Alternative Group).
[http://tox.umh.es/aetox/gtema/] Asociación Española de Toxicología -
Grupo Especializado de Trabajo en Métodos Alternativos.
(0-4)
ECVAM (European Centre
for Validation of Alternative Methods).
[http://ecvam.jrc.it/] .
(0-5)
ECVAM-SIS (Scientific
Information Service of the European Centre
for the Validation of Alternative Methods (ECVAM).
[http://ecvam-sis.jrc.it/] ECVAM-SIS is designed to establish,
maintain and manage a database (SIS) on advanced alternative procedures to animal
experiments. SIS is designed to provide full method descriptions including their
development and validation status..
(0-6)
ICCVAM - NICEATM (US).
[http://iccvam.niehs.nih.gov] ICCVAM. The Interagency Coordinating
Committee on the Validation of Alternative Methods. NICEATM. The National Toxicology
Program Interagency Center for the Evaluation of Alternative Toxicological Methods.
(0-7)
ESACT.
[http://www.esact.org/] European Society for Animal Cell
Technology.
(0-8)
EATB.
[http://www.eatb.de/] European Association of Tissue Banks.
(1-9)
Alternatives to Use of
Live Vertebrates....
[http://sis.nlm.nih.gov/] National Library of Medicine, NIH,
quarterly bibliography with abstracts, V. Hudson & E. DeBerry..
(1-10)
Amended EU Council
Directive 76/768/EEC - Cosmetic Products.
[http://europa.eu.int/eur-lex/en/com/pdf/2000/en_500PC0189.pdf] Proposal to amend EU Council Directive
76/768/EEC on the approximation of the laws of the Member States relating to cosmetic
products (2000). To introduce permanently and definitively a prohibition on the
performance of experiments on animals for finished cosmetic products in the territory of
Member States of the European Union..
(1-11)
ECVAM (European Centre
for the Validation of Alternative Methods) SIS (Scientific Information Service).
[http://ecvam-sis.jrc.it/] One of ECVAM's priorities is to
establish, maintain and manage a database (SIS) on advanced alternative procedures to
animal experiments. SIS is designed to provide full method descriptions including their
development and validation status. Furthermore, detailed protocols for their use, test
compounds to which they have been applied, and test results, information on user
laboratories and details on formal validation studies, are made available..
(1-12)
EEC (European Economic
Council) European Commission (on AltWeb).
[http://www.jhsph.edu/~altweb/science/regs/target2000.htm] Commission Directives identified. Description of European efforts to reduce and
eliminate animal testing..
(1-13)
Europa - Scientific
Committee for Cosmetic Products and Non-food Products (SCCNFP).
[http://europa.eu.int/] The European Commission Directorate
General Consumer Policy and Consumer Health Protection.
SCCNFP is sci. advisor to EC with a working group on alternatives to animal
testing. Cooperates with ECVAM..
(1-14)
FRAME (Fund for the
Replacement of Animals in Medical Experiments).
[http://www.frame.org.uk/index.htm] Numerous links to alternative testing
and animal care sites & listservs..
(1-15)
NIEHS and the Use of
Alternative Methods in Toxicological Research and Testing.
[http://www.niehs.nih.gov/oc/factsheets/analt.htm] Q & A 5-page fact sheet on
alternative methods for lay public..
(1-16)
NTP (National
Toxicology Program) 1998 Overview: Current Directions and Evolving Strategies.
[http://ntp-server.niehs.nih.gov/Main_Pages/PUBS/1998_overview.html] Development, validation, and regulatory
acceptance of improved alt. toxicol. methods. Model
systems include transgenic mice, nonmammalian species, in vitro cell systems, and
computer-based predictive models. ICCVAM and
1997 report & alt. toxicol. models advisory committee described..
(1-17)
NTP (National
Toxicology Program) Fiscal Year 1997 Annual Plan Summary.
[http://ntp-server.niehs.nih.gov/Main_Pages/PUBS/FY97_AP_Summ1.html] Section on Alternative/Complementary
Methods describes ICCVAM, previous funding on alt. models.
"The scope of alternative systems is envisioned to include
non-mammalian species, transgenics, use of mechanistic data in hazard identification, and
predictive toxicology.".
(1-18)
Swedish Fund for
Research without Animal Experiments, Links page.
[http://www.algonet.se/~stifud/links.html] Links to many alternatives sites
including AWIC, NORINA, alt. in higher education..
(1-19)
The Norwegian Reference
Centre for Lab. Animal Sci. & Alternatives -
Alternatives Databases.
[http://oslovet.veths.no/databases.html] Animal welfare links, link to CAAT
(mirror site)..
(1-20)
UC (University of
California - Davis) Center for Animal Alternatives Links page.
[http://www.vetmed.ucdavis.edu/Animal_Alternatives/weblinks.htm] Electronic mailing lists include
AltAnim (Alternatives to Animals Forum) and the Rat Talk listserv. Web site links include AWIC, NetVet, and
USDA/APHIS. Another page gives alternatives
terminology to use in online searches.
(2-21)
AltWeb Links.
[http://altweb.jhsph.edu/about-us/links.htm] Links to U.S. & foreign sites re:
animal welfare & regulations; also regs. themselves..
(2-22)
APHIS (Animal and Plant
Health Inspection Services), USDA, Animal Care Home Page.
[http://www.aphis.usda.gov/] Protects America's animal and plant
resources by safeguarding resources from exotic invasive pests and diseases, monitoring
and managing agricultural pests and diseases existing in the United States, resolving and
managing trade issues related to animal or plant health, and ensuring the humane care and
treatment of animals..
(2-23)
ASTM (Am. Soc. for
Testing and Materials).
[http://www.astm.org/] Standard methods for animal testing. Methods include GPMT [F720-81(1996)e1], delayed
hypersensitivity, acute oral toxicity, eye irrit..
(2-24)
BgVV (Bundesinstitut
fuer gesunheitlichen Verbraucherschutz und Veterinaermedizin).
[http://www.bgvv.de/] Animal protection, care, and use in
testing. Web pages are in German and have
not been translated as of May 22, 1998..
(2-25)
FRAME (Fund for the
Replacement of Animals in Medical Experiments).
[http://www.frame.org.uk/index.htm] Numerous links to alternative testing
and animal care sites & listservs.
(3-26)
EPA (U.S. Environmental Protection Agency) skin
sensitization guidelines via AltWeb.
[http://altweb.jhsph.edu/~altweb/regulations/EPA/2600_ss.htm] OPPT 40 CFR 870.2600 Skin Sensitization
(downloaded Jun. 1997 public draft). Full
text of harmonized test guideline used OPPT 40 CFR 798.4100 Dermal Sensitization; OPP 81-6
Dermal Sensitization (Pesticide Assessment Guidelines, subdivision F--Haz. Evaln.; Human
& Domestic Animals, 1982; and OECD 406 Skin Sensitization. If positive in LLNA,
further testing not needed..
(3-27)
(Center for Food Safety
and Applied Nutrition) - Office of Food Additive Safety.
[http://www.cfsan.fda.gov/~dms/opa-tg1.html] Toxicological testing of food
additives. Safety evaluation for a food additive involves assigning the additive to a
concern level based on information on the additive's structural configuration and an
estimation of exposure. This document has been prepared to recommend the minimum toxicity
tests to be performed for safety evaluation of indirect and direct additives based on
levels of concern. 1997 update to reformat.
Toxicity testing (protocols in FDA Redbook) does not include skin tests..
(3-28)
ASTM (Am. Soc. for
Testing and Materials).
[http://www.astm.org/] Methods include GPMT
[F720-81(1996)e1], delayed hypersensitivity, acute oral toxicity, eye irrit..
(3-29)
CPSC (Consumer Product
Safety Commission) Hazard Assessment and Reduction Program and Regulated Products Program.
[http://cpsc.gov/] Consumer Products Safe Testing Act;
Animal testing policy 49 FR 22522-22523 (1984); Guidelines for determining chronic
toxicity according to Federal Hazardous Substance Act. Poison Prevention Pkg. Act..
(3-30)
DoT Research and
Special Programs Administration.
[http://www.rspa.dot.gov/] Performance-oriented packaging
standards; Changes to classification, hazard communication, packaging, based on UN
standards and agency initiative, 55 FR 52402-52729; 49 CFR 173 (1990). 1994 DOT Strategic Plan. Statute is Federal Hazardous Materials
Transportation Law. DoT has accepted the
Corrositex method to predict corrosivity of test materials..
(3-31)
EPA (U.S. Environmental
Protection Agency) skin sensitization guidelines via AltWeb.
[http://altweb.jhsph.edu/~altweb/regulations/EPA/2600_ss.htm] OPPT 40 CFR 870.2600 Skin Sensitization
(downloaded Jun. 1997 public draft). Full
text of harmonized test guideline used OPPT 40 CFR 798.4100 Dermal Sensitization; OPP 81-6
Dermal Sensitization (Pesticide Assessment Guidelines, subdivision F--Haz. Evaln.; Human
& Domestic Animals, 1982; and OECD 406 Skin Sensitization. If positive in LLNA,
further testing not needed..
(3-32)
EPA NCEA (National
Center for Environmental Assessment).
[http://www.epa.gov/ncea/] Risk guidelines, exposure factors,
integrated model evaluation system..
(3-33)
EPA OPPT (Office of
Pollution Prevention and Toxics).
[http://www.epa.gov/opptintr/chemtest/] Describes chemicals not covered in
purview of TSCA. TSCA sections, Master
Testing List, Screening Information Dataset (SIDS), etc..
(3-34)
FDA CBER (Center for
Biologics Evaluation and Research) Guidelines/Guidances.
[http://www.fda.gov/cber/] Guidance and draft guidance. Files available for download in various formats. No guidelines obviously related to contact
hypersensitivity..
(3-35)
FDA CDER (Center for
Drug Evaluation and Research) Regulatory and Scientific Guidance.
[http://www.fda.gov/cder/regulatory/default.htm] Files available for download in various
formats. Clinical, bioequivalence and
solubility, some preclinical testing regulatory guidance..
(3-36)
ICH (International
Conference on Harmonisation).
[http://www.pharmweb.net/pwmirror/pw9/ifpma/ich1.html] Tech. requirements for registration of
pharmaceuticals for human use. Guidelines for
toxicity testing (no obvious one for dermal sensitization) can be downloaded (pdf)..
(3-37)
This FDA CFSAN Food
additives page available at AlWeb.
[http://altweb.jhsph.edu/~altweb/regulations/food-additives.htm] .
(3-38)
Amended EU Council
Directive 76/768/EEC - Cosmetic Products.
[http://europa.eu.int/eur-lex/en/com/pdf/2000/en_500PC0189.pdf] Proposal to amend EU Council Directive
76/768/EEC on the approximation of the laws of the Member States relating to cosmetic
products (2000). To introduce permanently and definitively a prohibition on the
performance of experiments on animals for finished cosmetic products in the territory of
Member States of the European Union..
(3-39)
BgVV (Bundesinstitut
fuer gesunheitlichen Verbraucherschutz und Veterinaermedizin).
[http://www.bgvv.de/] Animal protection, care, and use in
testing. [English version available].
(3-40)
EEC (European Economic
Council) European Commission on AltWeb.
[http://altweb.jhsph.edu/~altweb/regulations/target2000.htm] Commission Directives identified. Description of European efforts to reduce and
eliminate animal testing..
(3-41)
European Convention for
the protection of vertebrate animals used for exptl. & other sci. purposes.
[http://www.uku.fi/laitokset/vkek/Sopimus/convention.html] Council of Europe guidelines for animal
welfare in testing. Full text of guidelines..
(3-42)
ICH (International
Conference on Harmonisation).
[http://www.ifpma.org/ich1.html] Tech. requirements for registration of
pharmaceuticals for human use. Guidelines for
toxicity testing (no obvious one for dermal sensitization) can be downloaded (pdf)..
(3-43)
MDSS (Medical Device
Safety Service).
[http://www.mdss.com/MDD/standards.htm] Standards in the Official Journal of
the European Communities. Testing standards
include EN 10993-10 (based on ISO 10993-10: 1995). EN
10993-10 is on Biol. Evaluation of Medical Devices-Part 10: Tests for Irritation and
Sensitisation..
(3-44)
OECD (Organization for
Economic Co-operation and Development).
[http://www.oecd.org/] Links to test guidelines, description
of cooperative efforts in chemicals programme. Testing
and assessment is one link. OECD Guidelines for the Testing of Chemicals availability..
(3-45)
United Kingdon House of
Lords Select Committee on Animals in Scientific Procedures Report, [July 24, 2002 - 82
pages].
[http://www.publications.parliament.uk/pa/ld/ldanimal.htm] On July 24, 2002, a select committee of
the British Parliament's House of Lords released its report on the use of animals in
scientific procedures. The report was the result of a year of investigation, hearings, and
consultations by the committee with a wide range of representatives from both the
biomedical research and animal rights activist communities..
(4-46)
AltWeb.
[http://altweb.jhsph.edu/] Top-notch resource on many issues
related to alternative testing, animal welfare, and guidelines & regulations both in
the US and the international community..
(4-47)
ECVAM - The European
Centre for the Validation of Alternative Methods.
[http://ecvam-sis.jrc.it/] Validating methods and strategies to
reduce or replace the use of live animals in laboratory studies..
(4-48)
FRAME (Fund for the
Replacement of Animals in Medical Experiments).
[http://www.frame.org.uk/index.htm] Numerous links to alternative testing
and animal care sites & listservs..
(4-49)
Lab Animal Magazine
Links Page.
[http://www.labanimal.com] Countless links related to alternative
methods, animal research, and animal welfare, resources, and publications..
(4-50)
Laboratory Animals
Internet Links (from NetVet Veterinary Resources).
[http://www.lal.org.uk] International organizations related to
the field of laboratory animal medicine & science..
(4-51)
NCA (The Netherlands
Centre Alternatives to Animal).
[http://www.nca-nl.org/] NCA is the central point in the
Netherlands for coordinating research and disseminating information on alternatives to
animal experiments. One of its important tasks is to support the Alternatives to Animal
Experiments Platform, in which the Dutch government, industry and animal protection
organisations collaborate. The NCA database comprises 3Rs research projects..
(4-52)
NSSN Search for
Standards.
[http://www.nssn.org/search.html] Adopted modifications of ISO 10993-10:
1995 are ANSI/AAMI/ISO 10993-10-1995, EN ISO 10993-10, and BS ISO 10993-10 for irritation
and sensitization. Other results listed 85
toxicity testing stds.: ASTM, BSI, CSA, ISO, DoD, ANSI, CNS, CHI, CEN..
(4-53)
Swedish Fund for
Research without Animal Experiments, Links page.
[http://www.algonet.se/~stifud/links.html] Swedish Fund for Research without
Animal Experiments. Links to many
alternatives sites including AWIC, NORINA, alt. in higher education..
(4-54)
UC (University of
California - Davis) Center for Animal Alternatives Links page.
[http://www.vetmed.ucdavis.edu/Animal_Alternatives/weblinks.htm] Electronic mailing lists include
AltAnim (Alternatives to Animals Forum) and the Rat Talk listserv. Web site links include AWIC, NetVet, and
USDA/APHIS. Another page gives alternatives
terminology to use in online searches..
(5-55)
EECDRG (European
Environmental and Contact Dermatitis Research Group).
[http://www.sdu.dk/health/homepages/eecdrg/links.htm] Members, links, abstracts. Links to DermIS, the Dermatology Internet
Service..
(5-56)
Trans-NIH Xenopus
Initiative Web Site.
[http://www.nih.gov/science/models/xenopus/] The NIH has recently constructed this
excellent resource on Xenopus research and initiatives. The site was developed to help
keep the public aware of NIH's progress and plans regarding support of the genomic and
genetic needs for Xenopus research. The site also provides links to community resources
and to information about courses, meetings and publications..
(5-57)
Xenopus tropicalis
resource.
[http://minerva.acc.virginia.edu/~develbio/trop/] A group that is developing X.
tropicalis as a model organism, led by Dr. Robert Grainger at UVA. This work is supported
by NIH grant RR13221.
(6-58)
Funding Sources listed
by country.
[http://altweb.jhsph.edu/databases/funding/funding.htm] AltWeb list of funding sources
available (domestic and international).
(6-59)
NIH Office of
Extramural Research Small Business Innovative Research (SBIR) Contract Proposals pages.
[http://grants.nih.gov/grants/funding/sbir.htm] .
(7-60)
OECD's Work on Good
Laboratory Practice (GLP) and Compliance Monitoring.
[http://www.oecd.org/env/glp] The Organisation for Economic
Co-operation and Development's (OECD) main page on GLPs. Many links to relevant
materials..
(7-61)
EPA's "Good
Laboratory Practice Standards" (40CFR160).
[http://iccvam.niehs.nih.gov/docs/EPA/epa-glp.htm] EPA's regulations for good laboratory
practices (GLPs). In plain text..
(7-62)
FDA's "Good
Laboratory Practice for Nonclinical Laboratory Studies" (21CFR58).
[http://iccvam.niehs.nih.gov/docs/FDA/fda-glp.htm] FDA's regulations for good laboratory
practices (GLPs). In plain text..
(8-63)
CAAT grants from 1982
to 2003.
[http://caat.jhsph.edu/programs/grants/grants.htm] Summary of Research Grants.
(8-64)
Modelling Conract
Dermatities.
[http://caat.jhsph.edu/programs/grants/98-99grants/magee.htm] "A New Approach to Modeling
Contact Dermatitis" Phillip S. Magee, PhD, BIOSAR REsearch Project, Vallejo, CA,
describes (computational chem.).
(8-65)
Research Grants
1998-1999,.
[http://caat.jhsph.edu/programs/grants/98-99grants/grants98-99.htm] Summary of Research Grants for
Non-Scientists.
(8-66)
ALTEX - Alternativen zu
Tierexperimenten (Alternatives to Animal Experiments).
[http://www.altex.ch/] News, links, online order form for
ALTEX..
(8-67)
EECDRG (European
Environmental and Contact Dermatitis Research Group).
[http://www.sdu.dk/health/homepages/eecdrg/links.htm] Members, links, abstracts. Links to DermIS, the Dermatology Internet
Service..
(8-68)
Eur-Lex (Europeae
Unionis Lex, a portal to European union law).
[http://www.europa.eu.int/eur-lex/en/index.html] European Union law & regulatory
documents available for downloading in pdf and html formats. See search results on animal testing..
(8-69)
FRAME (Fund for the
Replacement of Animals in Medical Experiments).
[http://www.frame.org.uk/index.htm] Numerous links to alternative testing
and animal care sites & listservs..
(8-70)
IEXAS (The Institute of
Experimental Animal Science), Osaka University Medical School.
[http://hayato.med.osaka-u.ac.jp/] Lab. animal care, livestock diseases..
(8-71)
Laboratory Animals
Internet Links (from NetVet Veterinary Resources).
[http://www.lal.org.uk] Nine-page list of organizations related
to the field of laboratory animal medicine & science..
(8-72)
SCOPE (Scientific
Committee on Problems of the Environment) Annual Report.
[http://www.icsu-scope.org/] SCOPE & IPCS Scientific Group on
Methodologies for the Safety Evaluation of Chemicals (SGOMSEC). Describes workshops including SGOMSEC 13, Alt.
methods for Safety Assessment of Chemicals. Workshop held in Feb. 1998 in London, UK..
(8-73)
Swedish Fund for
Research without Animal Experiments, Links page.
[http://www.algonet.se/~stifud/links.html] lLinks to many alternatives sites
including AWIC, NORINA, alt. in higher education..
(8-74)
The Norwegian Reference
Centre for Lab. Animal Sci. & Alternatives Databases.
[http://oslovet.veths.no/databases.html] Animal welfare links, link to CAAT
(mirror)..
(9-75)
ATSDR (Agency for Toxic
Substances and Disease Registry).
[http://www.atsdr.cdc.gov/] ATSDR performs specific functions
concerning the effect on public health of hazardous substances in the environment..
(9-76)
CPSC (Consumer Product
Safety Commission) Hazard Assessment and Reduction Program and Regulated Products Program.
[http://cpsc.gov/] Consumer Products Safe Testing Act;
Animal testing policy 49 FR 22522-22523 (1984); Guidelines for determining chronic
toxicity according to Federal Hazardous Substance Act. Poison Prevention Pkg. Act. No testing information links from home page..
(9-77)
DoT (Department of
Transportation) Research and Special Programs Administration.
[http://www.rspa.dot.gov/] Performance-oriented packaging
standards; Changes to classification, hazard communication, packaging...based on UN
standards and agency initiative, 55 FR 52402-52729; 49 CFR 173 (1990). 1994 DOT Strategic Plan. Statute is Federal Hazardous Materials
Transportation Law. DoT has accepted
the Corrositex method to predict corrosivity of test materials..
(9-78)
EPA NCEA (National
Center for Environmental Assessment).
[http://www.epa.gov/ncea/] Risk assessment; risk guidelines,
exposure factors, integrated model evaluation system..
(9-79)
EPA OPPT (Office of
Pollution Prevention and Toxics).
[http://www.epa.gov/opptintr/chemtest] Describes chemicals not covered in
purview of TSCA. TSCA sections, Master
Testing List, Screening Information Dataset (SIDS), etc..
(9-80)
FDA CBER (Center for
Biologics Evaluation and Research) Guidelines/Guidances.
[http://www.fda.gov/cber/] FDA CBER guidance and draft guidance. Files available for download in various formats. No guidelines obviously related to contact
hypersensitivity..
(9-81)
FDA CDER (Center for
Drug Evaluation and Research) Regulatory Guidance.
[http://www.fda.gov/cder/regulatory/default.htm] Files available for download in various
formats. Clinical, bioequivalence and
solubility, some preclinical testing regulatory guidance.
No obvious contact hypersensitivity..
(9-82)
FDA CDRH (Center for
Devices and Radiological Health) Immunotoxicity Testing Guidance (May 6, 1999).
[http://www.fda.gov/cdrh/ost/ostggp/immunotox.html] Immunotoxicity testing guidance (May 6,
1999). FDA modification of ISO-10993 (adopted General Program Memorandum G95-1 in May
1995. Full text of guidance. This guidance
provides assessment of the types of testing currently available for evaluating potential
adverse effects of biomaterials on the immune system.
LLNA is mentioned in Table 3, Examples of Tests, Indicators, and
Models for the Evaluation of Immune Responses..
(9-83)
National Library of
Medicine (V. Hudson alt. tox. bibliographies).
[http://sis.nlm.nih.gov/] NLM bibliographies with abstracts on
Alternatives to Use of Live Vertebrates..
(9-84)
NIEHS Alternative
Models, Toxicology Operations Branch.
[http://dir.niehs.nih.gov/dirtob/stokes.htm] Collaborative development and
validation of improved (alt.) animal models and toxicol. res. methods. Gives publications by Dr. W.S. Stokes..
(9-85)
NIEHS Alternative
Systems Group.
[http://dir.niehs.nih.gov/dirlt/burkhart.htm] Gives overview of research on
correlation of induced mutation in cells, rodents, and aquatic species..
(9-86)
NIEHS and the Use of
Alternative Methods in Toxicological Research and Testing.
[http://www.niehs.nih.gov/oc/factsheets/analt.htm] Q & A 5-page fact sheet on
alternative methods for lay public..
(9-87)
NIEHS, Transgenic Model
Studies.
[http://ntp-server.niehs.nih.gov/Main_Pages/transgen/TransgenicPage.html] NIEHS Cancer Biology Group, Lab. of
Environ. Carcinogenesis and Mutagenesis, NTP. Test
protocols in p53-deficient and TG.AC transgenic mice.
Description of res. initiatives, hypothesis, approach, & publications..
(9-88)
NTP (National
Toxicology Program) Fiscal Year 2001 Annual Plan Summary.
[http://ntp-server.niehs.nih.gov/htdocs/2001ap/ap2001.pdf] Section on Alternative/Complementary
Methods describes ICCVAM, previous funding on alt. models.
The scope of alternative systems is envisioned to include
non-mammalian species, transgenic species, genetically engineered in vitro cell systems,
microchip array technology, and computer-based predictive toxicology models..
(9-89)
NTP 2002 Overview:
Current Directions and Evolving Strategies.
[http://ntp-server.niehs.nih.gov/Main_Pages/PUBS/2002CurrentDirections.pdf] Development, validation, and regulatory
acceptance of improved alt. toxicol. methods. Model
systems include transgenic mice, nonmammalian species, in vitro cell systems, microchip
array technology, and computer-based predictive models.
ICCVAM and SACATM described..
(10-90)
"Corrositex®
Report Released" (NIEHS) Jun. 22, 1999.
[http://www.niehs.nih.gov/oc/news/corros.htm] "Corrositex® Report
Released" (NIEHS) Jun. 22, 1999.
(10-91)
"Drop of 30
Percent in use of Animals(NIEHS) Oct. 3, 2001
http://www.niehs.nih.gov/oc/news/anitest2.htm
"Drop of 30
Percent in use of Animals in Some Tests Could Be Quickly Achieved Through Use of Cells,
U.S. Says" (NIEHS) Oct. 3, 2001
http://www.niehs.nih.gov/oc/news/anitest2.htm.
[http://www.niehs.nih.gov/oc/news/corros.htm] "Corrositex® Report
Released" (NIEHS) Jun. 22, 1999.
(10-92)
"Good News for
Guinea Pigs" (Science Magazine) Oct. 02, 1998.
[http://www.sciencemag.org/content/vol282/issue5386/r-samples.shtml] "Good News for Guinea Pigs"
(Science Magazine) Oct. 02, 1998.
(10-93)
"More Valid, Less
Guinea Pigs" (Lab Animal Magazine) Nov. 1998.
[http://www.labanimal.com] "More Valid, Less Guinea
Pigs" (Lab Animal Magazine) Nov. 1998.
(10-94)
"New NTP Centers
Meet the Need to Know" (EHP) Magazine) Oct. 1998.
[http://ehpnet1.niehs.nih.gov/docs/1998/106-10/niehsnews.html] "New NTP Centers Meet the Need to
Know" (Environmental Health Perspectives (EHP) Magazine) Oct. 1998.
(10-95)
"New Tricks for an
Old Assay"(EHP) Magazine) Oct. 1998.
[http://ehpnet1.niehs.nih.gov/members/1998/106-10/innovations.html] "New Tricks for an Old Assay"
(Environmental Health Perspectives (EHP) Magazine) Oct. 1998.
(10-96)
"NIEHS' Dr. Stokes
Receives Humane Society Award" (NIEHS) Oct. 29, 1998.
[http://www.niehs.nih.gov/oc/news/stokawd.htm] "NIEHS' Dr. Stokes Receives Humane
Society Award" (NIEHS) Oct. 29, 1998.
(10-97)
"Smoothing the Way
for Animal Alternatives" (Science Magazine) Apr. 04, 1997.
[http://www.sciencemag.org/content/vol276/issue5309/r-samples.shtml] "Smoothing the Way for Animal
Alternatives" (Science Magazine) Apr. 04, 1997.
(10-98)
"Stokes
Recognized" (EHP) Feb. 1999.
[http://ehpnet1.niehs.nih.gov/docs/1999/107-2/niehsnews.html#stokes] "Stokes Recognized"
(Environmental Health Perspectives) Feb. 1999.
(10-99)
"U.S. scientists
endorse change in animal testing" CNN Interactive Sept. 21, 1998.
[http://iccvam.niehs.nih.gov/methods/llnadocs/cnnstory.htm] "U.S. scientists endorse change in
animal testing" (originally appeared on CNN Interactive, reproduced with permission
from Reuters) Sept. 21, 1998.
(10-100)
Environmental Health
Perspectives Issue Updates Alternative Testing Advances (NIEHS) Jun. 22, 1998.
[http://www.niehs.nih.gov/oc/news/stokes2.htm] Environmental Health Perspectives Issue
Updates Alternative Testing Advances (NIEHS) Jun. 22, 1998.
(10-101)
New Agency Review Skin Sensitivity Test (NIEHS) Sept. 10, 1998.
[http://www.niehs.nih.gov/oc/news/animalt.htm] New Agency Group to Review Proposed Use
of Skin Sensitivity Test Using Fewer Animals (NIEHS) Sept. 10, 1998.
(10-102)
Reports Progress in
Using Fewer Animals, (NIEHS) Feb. 11, 2002.
[http://www.niehs.nih.gov/oc/news/iccvam.htm] "Federal Government Reports
Progress in Using Fewer Animals, More Humane Tests for Product Safety Evaluations"
(NIEHS) Feb. 11, 2002.
(10-103)
U.S. Agencies Agree on
How to Bring Alternative Testing Methods (NIEHS) - Mar. 13, 1997.
[http://www.nih.gov/news/pr/mar97/niehs-13.htm] U.S. Agencies Agree on How to Bring
Alternative Testing Methods Into Use to Supplement, Replace or Improve Current Tests
(NIEHS) - Mar. 13, 1997.
(11-104)
Animals in Research The
Importance of Animals in the Science of Toxicology.
[http://www.toxicology.org/publicoutreach/air/brochure.html] Society of Toxicology Brochure, March
1999.
(11-105)
NIEHS and the Use of
Alternative Methods in Toxicological Research and Testing.
[http://www.niehs.nih.gov/oc/factsheets/analt.htm] NIEHS Fact Sheet and Pamphlets Page.
Fact sheet on toxicology and carcinogenicity studies using animals, the pursuit of
alternative methods (including in vitro methods and computer models), appreciation of the
3 R's, and NIEHS' role in advancing these technologies and developing alternative methods.
(11-106)
Respect for Life Why
Animal Research?.
[http://www.niehs.nih.gov/oc/factsheets/fsmenu.htm] NIEHS Fact Sheet and Pamphlets Page.
(11-107)
You and Your Genes
Making it in a Tough Environment.
[http://www.niehs.nih.gov/kids/genes/home.htm] NIEHS Kid's Page. NIH Publication #
98-4367.
(12-108)
Advisory Committee for
Alternative Toxicological Methods (SACATM).
[http://ntp-server.niehs.nih.gov/htdocs/Liason/SACATM_FR.html] Notice of establishment of the
Scientific Advisory Committee for Alternative Toxicological Methods (SACATM) - March 13,
2002 (67 FR 11358).
(12-109)
Announcement.
Availability of the validation and acceptance of toxicological test methods.
[http://ntp-server.niehs.nih.gov/htdocs/Liason/ICCVAM_FR.html] Announcement of the availability of the
validation and regulatory acceptance of toxicological test methods: A Report of the ad hoc
Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), NIH
Publication 97-3981. - Mar. 13, 1997 (62 FR 11901).
(12-110)
current validation
status of the Frog Embryo Teratogenesis Assay--Xenopus (FETAX),.
[http://ntp-server.niehs.nih.gov/htdocs/liason/May16to18FETAXmtgFR.html] Notice of Expert Panel Meeting ( May 16
- 18, 2000) to assess the current validation status of the Frog Embryo Teratogenesis
Assay--Xenopus (FETAX), an in vitro method proposed for evaluating the developmental
toxicity potential of chemicals - Mar. 13, 2000 (65 FR 13289).
(12-111)
EPISKIN ™,
EpiDerm™ , and Rat Skin Transcutaneous Electrical Resistance Methods Sep 2001.
[http://ntp-server.niehs.nih.gov/htdocs/Liason/RSkinCorrosivity_FR.html] Availability of BRD: the EPISKIN
™, EpiDerm™ , and Rat Skin Transcutaneous Electrical Resistance Methods: In
Vitro Test Methods Proposed for Assessing the Dermal Corrosivity Potential of Chemicals;
Proposed ICCVAM Test Method Recommendations and Request for Public Comment - Sep. 28, 2001
(66 FR 49685).
(12-112)
Evaluation of the
Revised Up-and-Down Procedure (UDP) Feb 2000.
[http://ntp-server.niehs.nih.gov/htdocs/liason/ICCVAMUpDownFR.html] Request for Data and Nomination of
Expert Scientists to Participate in the Independent Peer Review Evaluation of the Revised
Up-and-Down Procedure (UDP) for Assessing Acute Oral Toxicity - Feb. 18, 2000 (65 FR
8385).
(12-113)
Expert Scientists for
an Independent Peer Review Evaluation of In Vitro Estrogen Receptor (ER) and Androgen
Receptor (AR).
[http://ntp-server.niehs.nih.gov/htdocs/liason/EDScreening_FR_2001Mar9.html] NICEATM, in collaboration with ICCVAM,
requests Data and Nominations of Expert Scientists for an Independent Peer Review
Evaluation of In Vitro Estrogen Receptor (ER) and Androgen Receptor (AR) Binding and
Transcriptional Activation Assays for Endocrine Disruptor Screening - Mar. 23, 2001 (66 FR
16278).
(12-114)
Federal Register
Notices ( linked from the NTP web site).
[http://ntp-server.niehs.nih.gov/Main_Pages/Announcements.html] Federal Register Notices ( linked from
the NTP web site).
(12-115)
Guidance Document on
Using In Vitro Data to Estimate In Vivo Starting Doses Sept 2001.
[http://ntp-server.niehs.nih.gov/htdocs/Liason/NICEATMIVWkspRpt_FR.html] Notice of the Report on the
International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity; Guidance
Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity;
Request for Public Comment - Sep.r 28, 2001 (66 FR 49686).
(12-116)
Guidelines for
Submissions to the Interagency Coordinating Committee on the Validation of Alternative
Methods (ICCVAM) Dec 1999.
[http://ntp-server.niehs.nih.gov/htdocs/liason/ICCVAMGuideFR.html] Availability and Request for Comments
on the Revised Guidance Document: Evaluation of the Validation Status of Toxicological
Methods: General Guidelines for Submissions to the Interagency Coordinating Committee on
the Validation of Alternative Methods (ICCVAM) - Dec. 2, 1999 (64 FR 67579).
(12-117)
In Vitro Test Methods
for Assessing the Dermal Corrosivity Potential of Chemicals - Jul. 31, 2002 (67 FR 49706).
[http://ntp-server.niehs.nih.gov/htdocs/Liason/CorrFinalRpt10Jul02FR.html] Availability of the Report, Interagency
Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Evaluation of
EPISKIN™, EpiDerm™ (EPI-200), and the Rat Skin Transcutaneous Electrical
Resistance (TER) Assay:.
(12-118)
Meeting Murine Local Lymph Node Assay (LLNA Jul 1998.
[http://ntp-server.niehs.nih.gov/htdocs/Liason/ICVAAM_LLNA_FR.html] Notice of Meeting to Review the Murine
Local Lymph Node Assay (LLNA) as an Alternative Test Method for Contact Hypersensitivity;
Request for Comments - Jul. 10, 1998 (63 FR 37405).
(12-119)
meeting (Conference
Call) of the National Toxicology Program Special Emphasis Panel (NTPSEP) Apr 1999.
[http://ntp-server.niehs.nih.gov/htdocs/Liason/CorrositexTeleconFR.html] Announcement of a public meeting
(Conference Call) of the National Toxicology Program Special Emphasis Panel (NTPSEP) on
April 22, 1999, to agree on the final report of the public meeting held on January 21,
1999, where an independent peer review of Corrositex®, a test method for dermal
corrosivity was conducted - Apr. 13, 1999 (64 FR 18040).
(12-120)
Meeting of the Advisory
Committee Feb 2000.
[http://ntp-server.niehs.nih.gov/htdocs/liason/ACATMMar7_82kFR.html] Meeting of the Advisory Committee on
Alternative Toxicological Methods on March 7-8, 2000, at NIEHS, 111 Alexander Drive, RTP,
NC - Feb. 16, 2000 (65 FR 7878).
(12-121)
Meeting of the Advisory
Committee Jul 1998.
[http://ntp-server.niehs.nih.gov/htdocs/Liason/AltToxMtg_FR.html] Announcement of a meeting of the
Advisory Committee on Alternative Toxicological Methods - Jul. 28, 1998 (63 FR 40302).
(12-122)
Meeting to Review the
Corrositex Assay Oct 1998.
[http://ntp-server.niehs.nih.gov/htdocs/Liason/Corrositex_FR.html] Notice of Meeting to Review the
Corrositex Assay as an Alternative Test Method for assessing the skin corrosivity
potential of chemicals; Request for Comments - Oct. 20, 1998 (63 FR 57303).
(12-123)
Meeting. Pprocedures
and activities of NICEATM and ICCVAM.
[http://ntp-server.niehs.nih.gov/htdocs/Liason/ICCVAM_11_97.html] Notice of meeting to discuss the
procedures and activities of NICEATM and ICCVAM - Oct. 27, 1997 (62 FR 55649).
(12-124)
Report of the
Interagency Coordinating Committee (ICCVAM)
Febn 2002.
[http://ntp-server.niehs.nih.gov/htdocs/Liason/ICCVAMAnnRptFR.html] Availability of the Annual Progress
Report of the Interagency Coordinating Committee on the Validation of Alternative Methods
(ICCVAM): Notice of Availability - Feb. 7, 2002 (67 FR 5845).
(12-125)
request for comments on
test methods undergoing Jul 1998.
[http://ntp-server.niehs.nih.gov/htdocs/Liason/ICCVAM_RFCmts_FR.html] Announcement of a request for comments
on test methods undergoing review by ICCVAM and NICEATM - Jul. 28, 1998 (63 FR 40303).
(12-126)
Request for comments on
validation and acceptance of alternative testing methods.
[http://ntp-server.niehs.nih.gov/htdocs/iccvam/AppendixG.html] Notice of a request for comments on
validation and acceptance of alternative testing methods - invitation to interested
parties to provide information for consideration in the formulation of criteria and
processes - Dec. 07, 1994 (59 FR 63100).
(12-127)
TEST METHODS PAGE..
[http://iccvam.niehs.nih.gov/methods/review.htm] FOR MORE RECENT FEDERAL REGISTER
NOTICES, PICK THE RELATED METHOD FROM THE.
(12-128)
The Revised Up-and-Down
Procedure (NIH) Feb 2002.
[http://ntp-server.niehs.nih.gov/htdocs/Liason/RevisedUPD_NICEATMFR.html] Availability of the UDP report:
"The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral
Toxicity of Chemicals," NIH Publication 02-4501 - Feb. 7, 2002 (67 FR 5842).
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